An embodiment of the invention provides an interference cancellation method and apparatus, which relate to the field of communication, for reducing the interference in a first communication system under a shared spectrum scene, thereby increasing the throughput of the first communication system. The interference cancellation method is applied to a first cell having a neighboring second cell. The first cell belongs to the first communication system, the second cell belongs to a second communication system, and the first cell and the second cell have a shared spectrum. The method comprises the steps of carrying out, by a base station of the first cell, interference pre-cancellation for a received uplink signal based on a preset strategy to obtain an interference pre-cancellation signal, the uplink signal including a first uplink signal transmitted by user equipment in the first cell and a second uplink signal transmitted by user equipment in the second cell; and eliminating an interference signal in the interference pre-cancellation signal based on a channel response estimated value of the interference pre-cancellation signal. The embodiment of the invention is applied between heterogeneous systems where the shared spectrum is present.