The invention relates to a cargo antitheft method and device based on Internet of vehicles. The method comprises steps that the target position information of a target address is acquired; a dynamic password is acquired; a safety secret key is generated according to the target position information and the dynamic password, and encryption locking is carried out according to the safety secret key; the safety secret key is sent. The method is advantaged in that the safety secret key is generated according to the target position information corresponding to the target address of a vehicle and the dynamic password inputted by a user, a bin gate of the vehicle is locked, cargo in the vehicle is with higher safety, and the cargo is effectively protected from being stolen.