The disclosure relates to an explosion suppression system and associated methods, which may include a cannon comprising a barrel and a propellant tank, a suppressant cartridge configured to be inserted into the barrel, and a triggering mechanism positioned between the barrel and propellant tank. The suppressant cartridge may be configured to operatively engage with a propellant source. One or more explosion sensors, which may be of different types, may be included in a system, and an explosion suppression device may be configured to activate when one or more of the sensors indicate an explosion. The disclosure further relates to a lock-out mechanism for an explosion suppression system, with the lock-out mechanism including a mechanical and/or electrical component. In one embodiment, an actuator may be positioned between a suppressant agent volume and a propellant agent volume of an explosion suppression system.