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发明公开
CN106660965A 乐伐替尼的对甲苯磺酸盐、其结晶形式及制备方法 无效 - 撤回

乐伐替尼的对甲苯磺酸盐、其结晶形式及制备方法
摘要：
本发明公开了乐伐替尼的对甲苯磺酸盐、其结晶形式及制备方法。具体地，本发明公开了乐伐替尼的对甲苯磺酸盐、其I型结晶及制备方法，所述制备方法包括将任意晶型或无定型的乐伐替尼对甲苯磺酸盐固体在单一的有机溶剂或者他们的混合有机溶剂中结晶得到乐伐替尼对甲苯磺酸盐I型结晶。本发明所得到乐伐替尼对甲苯磺酸盐I型结晶具备良好的晶型稳定性和化学稳定性，并且所用结晶溶剂低毒低残留。
摘要（英）：

Disclosed are p-toluenesulfonic acid salt of lenvatinib, crystalline form and preparation method thereof. Particularly, disclosed are p-toluenesulfonic acid salt of lenvatinib, crystalline form I and preparation method thereof. The preparation method comprises: crystallizing solid of any crystalline or amorphous p-toluenesulfonic acid salt of lenvatinib in a sole organic solvent or a mixed organic solvent thereof to obtain crystalline form I of the p-toluenesulfonic acid of lenvatinib. The obtained crystalline form I of the p-toluenesulfonic acid salt of lenvatinib in the present invention has good polymorphic stability and chemical stability, and the solvent used for crystallization has low toxicity and low residue.

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