The invention discloses a pressurizing needle-free injection device. The device comprises a tube body, a reversing valve, a control valve, a pressurizing valve, a piston, a medicine storage tube and a push rod. The reversing valve is arranged at one end of the tube body, and the end, provided with the reversing valve, of the tube body is sleeved with the control valve; the end, away from the reversing valve, of the tube body is fixedly provided with the medicine storage tube through an end cap; the end, provided with the medicine storage tube, of the tube body is sleeved with the pressurizing valve; the control valve is provided with a first ventilation pipe, a second ventilation pipe and a third ventilation pipe; the pressurizing valve comprises a first push plate, a second push plate, a second core sleeve, a pressurizing chamber and a reset chamber, the pressurizing chamber is separated from the reset chamber by the first push plate, the second push plate is arranged in the second core sleeve, and the first push plate and the second push plate are connected through a connection rod; the pressurizing valve is arranged, large pressure is obtained after external air pressure is pressurized by the pressurizing valve, so the injection effect is good; besides, externally supplied air pressure can be reduced; due to cooperation of the control valve and the reversing valve, automatic reset of the pressurizing valve can be controlled, and operation is easy.