The invention discloses an express item packing box and an application method thereof. The express item packing box comprises a box body and an embedded device. The embedded device is composed of a microprocessor, a power module, a non-contact IC card chip and an OLED display screen. When a sender sends an express item, information needed for express item sending can be written in the non-contact IC card chip through a computer and a non-contact IC card reader-writer, and corresponding input information will be displayed on the OLED display screen. According to the express item packing box and the application method thereof, the problems caused by the situation that handwriting is poor when the sender writes the information of a recipient and the like can be avoided, and information stored by the non-contact IC card chip can be read by a machine and sorted fully automatically. An express company can take back the embedded device when the recipient fetches the express item, and the embedded device can continue to be used on other box bodies.