The invention discloses a method for pretreating wastewater in an industrial zone based on coupling oxidation of catalyzed iron reduction and an application thereof, and belongs to the technical field of organic industrial wastewater treatment. The process is carried out as described in the description. According to the characteristics of wastewater quality of an industrial zone, a treatment technology based on coupling oxidation of catalyzed iron reduction is adopted, an industrial zone wastewater pretreatment technology of 'reductively promoting wastewater B/C and reducing biotoxicity and oxidatively subtracting biologically inhibited organic pollutant ingredients' is developed, the wastewater biodegradability can be remarkably improved, and toxic action of toxic substances in waste water on microorganisms can be effectively reduced. The method has the advantages of stable treatment effect and strong impact resistance, provides excellent pretreatment technical guarantee to up-to-standard emission of wastewater treatment in the industrial zone and upgrading and reconstruction, and has an excellent popularization and application prospect.