The invention relates to the field of dental medical treatment and in particular discloses fluorine-strengthened bioactivity mineral powder and a preparation method and an application thereof. The component system of constitution of the mineral powder is as follows: SiO-CaO-Na2O-P2O5-F. The powder comprises the following components in percentages by weight: 40-55% of SiO2, 15-30% of CaO, 15-30% of Na2O, 2-12% of P2O5 and 0.01-6% of F. According to the invention, by taking sodium monofluorophosphate as an importing components of fluorine element and controlling the mass ratio of sodium monofluorophosphate and phosphorus pentoxide added at 0.8-1.2, in a processing course, the loss of a volatile matter phosphorus pentoxide can be effectively reduced at a melting temperature of a material, so that calcium, phosphorus and fluorine in the material better meets a pre-designed proportion. By means of a shock chilling function of water, the amorphous state with more intermediate states is more easily formed, so that more crystal hydroxyapatite is formed during a reaction with water and is of higher activity. In the reaction process of the mineral powder and water, a phosphate component is further generated, thereby forming a better environment for generation of hydroxyapatite.