The invention relates to a C-2 site and C-7 site modified 1-deoxybaccatin VI taxane compound and a preparation method thereof. The structure of the compound is shown as a formula in the specification, wherein R is a benzoyl substituent group and a penta-heterocycle substituent group. According to the 1-deoxybaccatin VI taxane compound provided by the invention, benzoxyformyl of a 1-deoxybaccatin VI taxane analogue is modified into acetoxy at a C-2 site and various substituent groups are introduced into a C-7 site, so that a ring skeleton of taxanes and necessary functional groups are kept and the variety of compounds is enriched; related data of a primary screening experiment, a stability experiment, a concentration gradient experiment and the like shows that the anti-inflammation property of one part of compounds is better than that of taxanes; and meanwhile, valuable references are provided for researches of an activity structure-function relationship of the compounds.