The invention discloses weather-proof polyvinyl chloride wallpaper comprising a polyvinyl chloride wallpaper layer and an antifouling surface layer. The antifouling surface layer is formed by an outer protective layer, a function layer and a bonding layer in a co-extruding mode. The outer protective layer is a fluorine-containing high polymer, the function layer is formed by mixing of the fluorine-containing high polymers, hot melt glue and functional addition agents, and the bonding layer is formed by mixing of the fluorine-containing high polymers and the hot melt glue. The antifouling surface layer is connected with the polyvinyl chloride wallpaper layer in a hot melt adhesion mode. A preparation process of the weather-proof polyvinyl chloride wallpaper comprises the following steps that the three layers, namely, the outer protective layer, the function layer and the bonding layer are subjected to co-extruding to form a film after pelleting according to a formula, and the antifouling surface layer is prepared and rolled for standby application; the bonding layer of the antifouling surface layer makes contact and is overlaid with the polyvinyl chloride wallpaper layer, and then pressed and composited; and then, embossing, slitting and rolling are carried out to obtain a product. The weather-proof polyvinyl chloride wallpaper has the advantages of strong stain resistance, chemical inertness, high abrasion resistance, environmental friendliness and weather resistance.