The invention is applicable to the technical field of nuclear power, and discloses a processing method and a processing device of a nuclear power station generator set relevant system. The method comprises the following steps of A, troubleshooting nuclear power station generator relevant pipelines during power operation to form a fault pipeline list; B, analyzing the reason of higher pipeline vibration in the fault pipeline list from two sides, i.e. an exciting force source and pipeline inherent frequency; and C, if the reason of higher pipeline vibration is the pipeline inherent frequency, designing a vibration reduction support, carrying out trial assembly and assessment, and confirming if the vibration can be effectively reduced and the field installation requirement is met, if yes, carrying out integral installation during overhaul, and if not, improving the arrangement of engine pipelines. According to the processing method and the processing device of the nuclear power station generator set relevant system provided by the invention, through troubleshooting of the pipelines in site, confirmation of a pipeline treatment range, comprehensive analysis of reasons, design of a scheme, and trial assembly and assessment in site, the major defect of high vibration of the engine relevant pipelines is thoroughly overcome, and a certain experiences and a scientific method are accumulated for vibration treatment of important pipelines.