The present disclosure discloses an audio output circuit including an audio power amplifier, a mute control circuit and a microcontroller, the audio power amplifier includes a power input terminal, a mute control terminal and an audio signal output terminal, the power input terminal is used to connect a power supply to obtain a power supply voltage, the mute control terminal is connected with the microcontroller through the mute control circuit and is grounded by a pull-down resistor, the audio signal output terminal is used to output an audio signal, the mute control circuit is also connected to the power supply for disconnecting the mute control terminal from the microcontroller when the power supply voltage is less than a preset voltage. The present disclosure also provides an audio device. According to the present disclosure, it is possible to effectively prevent the POP sound of the speaker of the audio device.