The invention provides a low-temperature-resistant ethylene propylene diene monomer door and window sealing strip formula. The formula is prepared from the following materials in parts by mass: 100 parts of ethylene propylene diene monomer, 8 parts of zinc oxide, 2 parts of stearic acid, 2 parts of anti-aging agent RD, 110 parts of N550 carbon black, 80 parts of paroline oil, 9 parts of vulcanizing agent BIBP-40, 1.5 parts of assistant crosslinker, 5 parts of fire retardant and 4 parts of blender. Low-temperature-resistant rubber is prepared through combination of the ethylene propylene diene monomer, the zinc oxide, the stearic acid, the anti-aging agent RD, the N550 carbon black, the paroline, the vulcanizing agent BIBP-40, the assistant crosslinker, the fire retardant and the blender; thus, a door and window sealing strip has the advantage of lower low-temperature compression set, and low-temperature elasticity of a product is remarkably improved.