The invention discloses a preparation method of Ni-coated mesoporous SiO2 conductive powder. According to the preparation method, mesoporous SiO2 power is adopted as a carrier; nickel salt is adopted as a precursor; oleic acid or oleate is added into an obtained solution, so that a uniform oleate coating can be formed; and the uniform oleate coating is subjected to thermal decomposition under protective atmosphere at 400 DEG C to 500 DEG C, so that Ni/SiO2 conductive powder can be formed. According to the preparation method of the invention, obtained Ni is dendritic and is dispersed uniformly on the mesoporous SiO2 carrier and has good electrical conductivity. According to the preparation process of the Ni-coated mesoporous SiO2 conductive powder of the invention, a reducing agent is not required, and therefore, the preparation method is environmentally friendly; and raw materials are highly available; and the preparation method is easy to operate and can meet the requirements of industrialization.