The invention relates to a five-prevention system for an intelligent substation. The five-prevention system is positioned in a monitoring system of the intelligent substation and is connected with an intelligent terminal and terminal equipment of the intelligent substation respectively. The five-prevention system comprises a monitoring-system background locking module, a spacing-layer locking module and an electric-loop locking module; the monitoring-system background locking module is connected with a monitoring database in the monitoring system and the electric-loop locking module respectively; the spacing-layer locking module is connected with the intelligent terminal; and the electric-loop locking module is connected with the terminal equipment. Compared with the prior art, the five-prevention system has the advantages of high informationization degree, convenience in remote-control operation and high safety performance and the like.