The invention discloses a medicine for treating pernicious vomiting and a preparation method of the medicine. The medicine is mainly prepared from stove earth cakes, bamboo shavings, ruddle, codonopsis pilosula, fructus amomi, perilla stems, perilla leaves, poria cocos, pomelo peel, coptis chinensis, reed rhizome, astragalus membranaceus, bamboo leaves, angelica sinensis, dried tangerine or orange peel, corn stigma, agastache rugosa, persimmon calyx, atractylodes macrocephala, rhizoma cyperi, desmodium triquetrum, chrysanthemum and liquorice in certain weight proportions. The medicine disclosed by the invention has the functions of tonifying the liver and kidneys, regulating qi-flowing and strengthening the spleen, clearing dampness and reducing phlegm as well as harmonizing the stomach and lowering adverse qi, and is high in effect taking speed, good in treatment effect and free of disease occurrence when being used for treating pernicious vomiting.