The invention provides a catheter connection device. The device comprises a proximal connector, a distal connector, a rotary connecting piece and two sets of profile connection pipes. The rotary connecting piece is rotationally connected between the proximal connector and the distal connector, and the ends, away from each other, of the proximal and distal connectors are connected with the two sets of profile connection pipes respectively; the interior of the proximal connector and the interior of the distal connector are both evenly provided with a set of catheter cavity channels in the rotation direction; the rotary connecting piece comprises a first end and a second end opposite to the first end; the interior of the rotary connecting piece is correspondingly provided with at least one set of catheter cavity channels in the rotation direction, the at least one set of catheter cavity channels converge flow from the first end to the second end of the rotary connecting piece, a rotary connector is rotated, the catheter cavity channels are communicated with the corresponding profile connection pipes, and fluid convergence in the catheter cavity channels is achieved. By means of the fluid convergence of the catheter connection device, the aperture utilization efficiency of a multi-cavity catheter can be maximal.