The invention discloses a three-dimensional laser cutting machine. The three-dimensional laser cutting machine comprises a machine tool, wherein the machine tool comprises an X-axis assembly used for driving a cutting head in an X direction, a Z-axis assembly used for driving the cutting head in a Z direction, a Y-axis assembly used for driving a workpiece in a Y direction, a workpiece rotary shaft assembly used for driving the workpiece to rotate, a cutting head rotary shaft assembly and a follower shaft assembly; the workpiece rotary shaft assembly is capable of driving the workpiece to rotate in the Z direction; the cutting head rotary shaft assembly is capable of driving the cutting head to rotate in the Y direction; the follower shaft assembly is arranged on the cutting head rotary shaft assembly; the cutting head is arranged in the follower shaft assembly; a capacitive sensor is arranged at the nozzle of the cutting head; and each two of the X direction, the Y direction and the Z direction are mutually vertical. The three-dimensional laser cutting machine further comprises a control terminal used for carrying out control operation on the machine tool. The follower shaft assembly is capable of automatically adjusting the height of the cutting head according to the change of the surface of a cutting sample to ensure a constant distance between the cutting head and the cutting sample during a three-dimensional laser cutting process, thereby solving the out-of-focus problem generated during a cutting process.