The invention relates to an ampoule bottle opener. The ampoule bottle opener is characterized by comprising a main shell, a grinding wheel polishing mechanism, a disinfection belt mechanism and a mechanical braking mechanism, and can synchronously perform three operation steps of polishing, disinfection and bottle opening; the polishing and the disinfection are synchronously finished once through the mechanical braking mechanism; the ampoule bottle opener is reasonable in overall structural design, has the advantages of small size and light mass, and is convenient to carry and use; the ampoule bottle opener opens ampoule bottles; when nipple parts are split from bottle bodies, the nipple parts can enter a recovery cavity through an elastic one-way part without contacting with hands of medical workers and injuring the medical workers; and meanwhile, the nipple parts have no need to be singly recovered, so that the working efficiency is improved.