The invention discloses a closed cycle preparation new process of zinc sulfate and zinc oxide, and belongs to the field of chemical engineering. The new process comprise a liquid preparing system procedure, a product preparation system procedure and a waste liquid treatment system procedure, wherein the liquid preparing system procedure is composed of the procedures of medium-acid leaching, oxidation for iron removal and oxidation for manganese removal of leaching agent, and replacement for impurity removal; the product preparation system procedure is composed of a preparation subsystem of zinc sulfate and a preparation subsystem of zinc oxide; the waste liquid treatment system procedure is composed of treatment procedures of generated waste liquid such as zinc sulfate separated mother liquid produced in the preparation sub-system of the zinc sulfate, an ammonium sulfate or sodium sulfate solution and basic zinc carbonate cleaning liquid produced in the preparation sub-system of the zinc oxide. The original production lines of singly producing the zinc sulfate and the zinc oxide are integrated and transformed into a closed cycle production system, the wastewater zero discharge is realized, the vicious circle of pollution-treatment-secondary pollution is avoided; the production of three-waste is controlled from the source so as to prevent the environment pollution, and the production cost is lowered, and the economic benefit is improved.