The invention discloses an integrated treatment method for high-salinity and high-concentration refractory organic wastewater resulted from cellulose ether production. The method comprises the steps of (1) carrying out pretreatment on to-be-treated wastewater through coagulating sedimentation and fenton reaction in sequence; (2) carrying out biochemical treatment on fenton reaction effluent through cellulase hydrolysis, anaerobic treatment, first-stage contact oxidation and second-stage contact oxidation in sequence, feeding cellulose to carry out degradation, anaerobic treatment, first-stage contact oxidation and second-stage contact oxidation processes on the wastewater in the cellulose hydrolysis process, adding a salt-tolerant fungicide of producing the cellulose ether to carry out strengthened treatment on the wastewater; and (3) carrying out deep treatment on second-stage contact oxidation effluent through the fenton reaction and finally discharging the effluent. Compared with an existing treatment method, the integrated technology has the characteristics of being high in pertinence, economic and environment-friendly; and problems that the wastewater is high in salinity, high in concentration and refractory are solved for enterprises that produce the cellulose ether.