The invention provides a preparation technology of dendrobium officinale kimura ex migo liquor rich in plant active substances and belongs to the technical field of medical health foods. A novel preparation technology of the dendrobium officinale kimura ex migo liquor is provided through dendrobium officinale kimura ex migo raw material selection, raw material pretreatment, base liquor selection, active substance extraction, concentration for alcohol dropping, enzymatic clarification, production cycle and the like. By taking fresh stems of dendrobium officinale kimura ex migo as the only raw material, liquor as a carrier and extraction of the active substances from the dendrobium officinale kimura ex migo as means, the preparation technology improves the utilization efficiency of the raw material and lowers the cost. The prepared dendrobium officinale kimura ex migo liquor has the alcoholic strength of 38-42 degrees, is slight yellow in color, long in aftertaste, pleasant in medicine smell and lustre, is crystal clear, mellow, sweet, fresh and clear, is higher in viscosity, good in convergence effect and rich in active substances including polysaccharide as well as amino acid, trace elements and the like essential to a human body. The preparation technology is short in production cycle, high in raw material utilization ratio, mild in processing condition, simple and conventional in involved equipment and liable to operate and does not use any food additive.