The invention provides a quick-response pneumatic hydraulic cylinder which comprises an upper cover, a cylinder barrel and a lower cover, and the upper cover, the cylinder barrel and the lower cover are sequentially connected. The quick-response pneumatic hydraulic cylinder further comprises a first sealing assembly which comprises two first guiding rings, a plurality of second guiding rings, a step seal and an AQ seal. The two first guiding rings are arranged at the two ends of the outer wall of a piston correspondingly, the second guiding rings are arranged between the two first guiding rings, the AQ seal is arranged between the first guiding ring close to the upper cover and the corresponding second guiding ring, and the step seal is arranged between the first guiding ring away from the upper cover and the corresponding second guiding ring. According to the quick-response pneumatic hydraulic cylinder provided by the invention, movement flexibility and stability of the piston and a piston rod can be improved, abrasion resistance is good, mutual seepage of internal hydraulic oil and internal high-pressure gas is prevented, and the overall service life is prolonged.