The invention discloses a pipeline clamp which comprises a clamp base, a sliding clamper and a rotating disc, wherein a first central hole and a plurality of sliding rails which are distributed circumferentially and extend axially are arranged on the clamp base; the sliding clamper is slidably matched with the sliding rails and is provided with a slide block and a mandrel; a clamping portion is arranged on the end portion of the mandrel; the rotating disc is rotatably connected to the clamp base and is provided with a second central hole; a slot corresponding to the sliding clamper is also formed in the rotating disc; the sliding clamper is slidably clamped in the slot through a block pin; the projection of the slot along the axial direction of a pipeline is intersected with that of the corresponding sliding rails along the axial direction of the pipeline; and one end, of the slot, to the other end is gradually separated from the center of the rotating disc. The pipeline clamp also comprises a positioner for fixing the position of the rotating disc. According to the scheme, the pipeline clamp can quickly clamp and loosen the pipeline, and the safety guarantee is also increased while the efficiency is improved; and the pipeline clamp is widely applied to various repair, maintenance and replacement works of deep-well pumps.