The invention relates to the technical field of supersonic wave cleaning, and more particularly, to a filter core clamping and supporting mechanism. The mechanism has a simple structure and can be conveniently mounted and dismounted. The mechanism comprises a rack. The rack is provided with an operation console. The operation console is provided with a water sink. The upper end of the water sink and the rack are provided with a longitudinal cylinder. The piston rod of the longitudinal cylinder is connected with a horizontal circular rod. One end of the horizontal circular rod is fixedly provided with a fixed plate while the other end is flexibly sleeved by a flexible plate. The inner side of the flexible plate and the horizontal circular rod are provided horizontally with a horizontal cylinder. The piston rod of the horizontal cylinder is connected with the flexible plate. The corresponding positions on the fixed plate and the flexible plate are provided with bearing seats respectively. The bearing seats are provided with rotation shafts therein. The rotation shafts are provided with round clamping grooves for the filter core. The rotation shafts on the fixed plate are exposed out of the outer side of the fixed plate and the end parts are provided with driven chain wheels. The upper end of the fixed plate is provided with a stepping motor. The output shafts of the stepping motor are provided with driving chain wheels. The driving chain wheels and the driven chain wheels are connected through the chains.