The invention discloses a method for improving the anti-interference performance of an ion migration tube and a processing circuit thereof, and aims to provide a method capable of significantly improving the anti-interference performance of an ion migration tube and a processing circuit thereof. The method comprises the following steps: arranging an additional sensor, of which the position corresponds to a signal extraction sensor, outside an ion migration tube body, wherein the structure of the additional sensor is the same as that of the signal extraction sensor, and a voltage the same as that applied to a metal gauze of the signal extractions sensor is applied to a metal gauze of the additional sensor to extract vibration signals; performing margin calculation on output signals of the signal extraction sensor and the additional sensor by using a differential amplifier, removing the vibration signals, and filtering out high-frequency parts in current signals obtained by the margin calculation by virtue of a low-pass filter, so as to obtain clean ionic current signals. According to the method provided by the invention, vibration interferences can be effectively reduced, and the detection precision of the ion migration tube is improved.