The invention relates to identification of cross-interference between workloads in compute-node clusters. A method includes monitoring performance of a plurality of workloads that run on multiple compute nodes. Respective time series of anomalous performance events are established for at least some of the workloads. A selected workload is placed on a selected compute node, so as to reduce cross-interference between two or more of the workloads, by comparing two or more of the time series.