The invention discloses a design method of a pipeline crossing strike-slip fault, and belongs to the field of the oil and gas pipeline crossing technology. The method comprises the steps that the maximum dislocation on the surface of the strike-slip fault is calculated, and the soil type of backfill, the buried depth of a pipeline, the type of a contact surface of the pipeline and soil and the included angle between the strike-slip fault and the pipeline are determined; parameters of the pipeline passing through the strike-slip fault are obtained, and the displacement of faults parallel to the axial direction of the pipeline and the fault displacement in the normal line direction of the pipeline are calculated; a finite element model is established, and the maximum strain of the pipeline during sliding of the strike-slip fault is simulated by means of the finite element model, a maximum strain empirical formula for the pipeline to cross the strike-slip fault is established, the undetermined parameters are fitted, and the numerical relationship between the maximum strain and the parameters is obtained. The design method of the pipeline crossing strike-slip fault fits out the formula suitable for designing the pipeline in the strike-slip fault because the actual change of the pipeline after the strike-slip fault slides is simulated by the finite element model, and therefore the pipeline corresponding to the fault with specific conditions can be accurately designed.