The invention discloses a power grid loss reduction effect comprehensive quantitative evaluation method after charge-network-source coordination control. An evaluation index computation and the loss reduction effect evaluation of an implementation effect are performed after adopting the charge-network-source coordination control loss reduction measure. From three perspectives of a power grid side, a power source side and a high-energy load side, the income and contribution of each main body are comprehensively considered, multiple influence factors are proposed, and multiple quantitative indexes are computed so as to evaluate the loss reduction effect. In the specific implementation, the charge-network-source coordination control loss reduction measure is selected to compute the quantitative numerical value of each index according to the historic numerical value and the measured numerical value, the system loss reduction effect is evaluate on this basis, and a corresponding loss reduction effect improving suggestion is offered. By evaluating the implementation effect of the charge-network-source coordination control loss reduction measure, the real effect of reducing the network loss by the charge-network-source coordination control loss reduction measure can be sufficiently reflected.