The invention discloses a high-voltage DC relay insulation frame, which comprises an insulation frame. The insulation frame is arranged on yoke iron. The insulation frame and the yoke iron are cooperated to form a cavity. The cavity is internally provided with a moving contact assembly and a static contact assembly. The moving contact assembly comprises a moveable spring plate. The yoke iron is provided with a positioning plate. The yoke iron and the positioning plate are respectively provided with a push rod through hole for allowing a push rod to pass. The upper section of the push rod is arranged above the yoke iron and is fixed to the moveable spring plate. The insulation frame and the positioning plate form a mutually-cooperated limit structure to enable the positioning plate to be fixed radially. The limit structure comprises insulation frame protrusions and positioning plate protrusions. The positioning plate protrusions are fixed to the upper end surface of the positioning plate and extend upwards; the insulation frame protrusions are fixed to the inner wall of the insulation frame; and when the insulation frame is cooperated with the yoke iron, the insulation frame protrusions are arranged in the positioning plate circumferential clockwise rotation direction and/ or anticlockwise rotation direction of the positioning plate protrusions.