The invention discloses a positive-sequence clockwise and negative-sequence anticlockwise compensation method of a high-voltage side for transformer differential protection. For transformer differential protection of 12 kinds of wiring groups, a zero-sequence current in a phase current is eliminated at a low-voltage side; and an A phase, a B phase, a C phase of a high-voltage side decomposed into positive sequence currents and negative sequence currents and zero sequence currents are eliminated automatically. All phases of currents of the positive sequence take the high-voltage side as a reference; and after clockwise rotation with n*30 degrees, the phases of all phases of currents are consistent with phases of all phases of currents at the low-voltage side. All phases of currents of the negative sequence take the high-voltage side as a reference; and after anticlockwise rotation with n*30 degrees, the phases of all phases of currents are consistent with phases of all phases of currents at the low-voltage side. And phases of all phases of currents at the high-voltage side after the synthesis of the positive sequence currents and the negative sequence currents are consistent with phases of all phases of currents at the low-voltage side. The compensation method is suitable for transformer longitudinal differential protection device of wiring groups with 1-to-12-point random combination at the high-voltage side of the transformer, so that the requirement of current phase compensation of transformer differential protection can be met.