The invention provides an overcurrent protection and latch prevention circuit, which comprises an on-off circuit, a current sampling and limiting circuit, a latch burp prevention circuit, a drive circuit and a power circuit. The overcurrent protection and latch prevention circuit has the beneficial effect that an MOSFET is selected by the circuit as a protection switch to control connecting and disconnecting of an input end of equipment and a bus. After a load generates a latch phenomenon, current is limited at a specified value, and the latch phenomenon of the load is eliminated through energization and interruption for a few times. If the load is in an over-current or short-circuit fault, the current is limited at the specific value, and the circuit is finally cut off after energization and interruption for a few times, so that load equipment is effectively protected, and after the load equipment is normal, the circuit can rework through adding a startup instruction, and has the functions of a fuse and relay.