The invention provides an optimization configuration method of an active filter. The optimization configuration method comprises the following steps of setting a target function according to influence on configuration of the active filter; setting a constraint condition conforming to optimization configuration of the active filter of an intelligent power distribution network; and performing optimization configuration on the active filter of the intelligent power distribution network by a configuration algorithm combined with a mode analysis method and a genetic algorithm. According to the optimization configuration method of the active filter, provided by the invention, a candidate position node of the active filter is determined by introducing the mode analysis method, the calculation quantity of the genetic algorithm for determining a configuration position of the active filter is reduced, and the problem that the genetic algorithm is easy to fall into local optimum is solved; and moreover, the operational speed of the optimization configuration method is fast, rapid convergence of the algorithm is facilitated, a better optimal solution can be found out, the optimal access position of the active filter can be effectively calculated, and the optimization configuration method has a good effect on improving the running economy of the system and improving the electric quality.