The invention discloses a secure data transmission method and device of middleware based on a hybrid cipher suite. The secure data transmission method is used by a client to obtain necessary data from a server securely. According to the secure data transmission method provided by the invention, the hybrid cipher suite is adopted during the secure data transmission between the middleware and the client, and the hybrid cipher suite comprises a national commercial asymmetric cryptography algorithm, a digest algorithm and a foreign standard symmetric cryptography algorithm. The secure data transmission between the middleware and the client comprises the following steps: firstly, in a secure connection establishment process of the middleware and the client, generating a symmetric key by using the hybrid cipher suite, and establishing a secure connection by the middleware and the client by comparing the digest values of both parties; and finally, encrypting the data necessary for the client by the middleware on the basis of the secure connection established by the both parties to obtain encrypted data, sending the encrypted data to the client, and decrypting the encrypted data by the client by using a negotiated key to obtain the necessary data.