The invention provides an evaluation method of multi-cycle carbon dioxide huff-puff in a heavy oil edge-bottom water reservoir based on moisture content. The evaluation method includes the following steps: determining actual parameters of various factors of actual oil reservoirs, on the basis of the actual parameters establishing a reservoir model, and then simulating to obtain the moisture content of well startup after huff-puff; taking the moisture content of the well startup after huff-puff as an evaluation association object to calculate revising weight of the various factors and build a membership degree computing method to obtain evaluation matrixes of a simulation scheme and an actual scheme, and then combining the revising weigh of the various factors to calculate and sort average value the average of C and Cj of integrate scores of all the factors of the simulation scheme and the actual scheme; comparing the size of the average of C and the Cj to give evaluation conclusions; if Cj > the average of C, the evaluation conclusion is better; if Cj < the average of C, the evaluation conclusion is worse. The evaluation method comprehensively reflects the action mechanism of the carbon dioxide huff-puff in water control and oil increase, and is of great significance for guiding the evaluation of the multi-cycle carbon dioxide huff-puff in a heavy oil edge-bottom water reservoir.