The invention discloses an automatic cleaning device of a flat panel display. The automatic cleaning device of the flat panel display comprises a supporting frame, a turbine booster pump and a liquid storage box. Conveyer belt pulleys are arranged above the supporting frame. A cooling fan is arranged outside the turbine booster pump. The right side of the turbine booster pump is connected with an air inlet through a dehumidification drying box. The right side of the liquid storage box is provided with a liquid inlet. The left side of the liquid storage box is connected with a cleaning roller through a liquid pump. A wiping roller is arranged on the left side of the cleaning roller. According to the automatic cleaning device of the flat panel display, the movable conveyer belt pulleys and the movable carrying clamps are arranged in the automatic cleaning device, the cleaning roller and the wiping roller are arranged inside the automatic cleaning device, so that after passing through the cleaning roller and the wiping roller, the flat panel display can be cleaned, and automatic cleaning is achieved; and finally, wind stopping curtains and air spray pipes are arranged on the two sides of the automatic cleaning device, air sprayed out by dry spray pipes is dry and clean air, and therefore it is effectively avoided that the flat panel display is contaminated by dust in the cleaning process.