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发明授权
CN106811539B LTA基因单核苷酸多态性rs2009658在检测结核易感性中的应用 有权

LTA基因单核苷酸多态性rs2009658在检测结核易感性中的应用
摘要：
本发明公开了LTA基因单核苷酸多态性rs2009658在检测结核易感性中的应用。本发明所提供的应用为用于检测rs2009658位点的单核苷酸多态性的物质在制备评价或辅助评价待测人患结核病的风险性的产品，或在制备诊断或辅助诊断待测人是否患有结核病的产品中的应用。本发明的发明人通过中国汉族人群病例对照研究发现LTA基因SNP‑rs2009658位点基因多态性与结核罹患风险之间存在显著的相关性。携带LTA‑rs2009658GC基因型和LTA‑TNF“GGCCG”单体型的人群在结核分枝杆菌感染时发病风险更高。本发明为炎性及免疫相关基因SNP与结核易感性之间的关联提供了新见解，对结核易感基因筛查与预防有重大价值。
摘要（英）：

The invention discloses application of LTA (Lymphotoxin Alpha) gene single nucleotide polymorphism rs2009658 to detection of tuberculosis (TB) susceptibility. The application provided by the invention refers to preparation of a product for evaluation or assistance in assessing TB-suffering risks of a person to be detected by substances for detecting the single nucleotide polymorphism of rs2009658 loci, or preparation of a product for diagnosis or auxiliary diagnosis on whether the person to be detected suffers from TB or not. The inventor of the invention finds that a significant correlation occurs between gene polymorphism of LTA gene SNP-rs2009658 loci and the TB suffering risks through case control studies of Chinese Han populations. The populations with LTA-rs2009658GC genotypes and LTA-TNF 'GGCCG' haplotypes are at higher onset risks for mycobacterium tuberculosis infection. The invention provides a new insight into the association between the inflammatory and immune-related genes SNP and the susceptibility to TB, and is of great values in the screening and prevention of TB susceptibility genes.

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