The invention discloses a cleaning and disinfecting device for nursing appliances of a supply room. The cleaning and disinfecting device comprises a moving vehicle body, wherein the upper end of the moving vehicle body is provided with a support pipe, a push handle and a display seat body; the outer part of the display seat body is provided with an indicator lamp; the inner cavity of the support pipe serves as a vapor passage, the upper end is provided with a socket, and the lower end is a closed end; multiple layers of disinfection disks and closed cover plates are sleeved at the outer side of the support pipe; each disinfection disk is composed of a sleeve pipe and a fan-shaped tray; the pipe wall of the sleeve pipe is provided with an outer air inlet; and the side part of the support pipe is provided with an inner air inlet. According to the invention, the moving vehicle body is used as a carrier to conveniently collect nursing appliances to be disinfected and transport disinfected nursing appliances, thereby avoiding repeated transfer; and the multiple disinfection disks are arranged, so that private disinfection disks can be allocated to each department, and tedious appliance classification does not need to be performed after disinfection, thereby saving manpower and facilitating appliance management.