The invention discloses a parameter configuration method and device of an electric bus. The method comprises the following steps that a plurality of parameters of the electric bus are obtained; a battery residual quantity matrix is built according to the battery residual quantity of the electric bus at every dispatch running time, and a battery charger charging state matrix is built according to the charging states of a battery charger at every dispatch running time; order of the battery residual quantity matrix is calculated, the minimum configuration quantity of the bus is obtained, order of the battery charger charging state matrix is calculated, and the minimum configuration quantity of the battery charger is obtained; and according to a pre-build consumption model, the minimum configuration quantity of the bus and the minimum configuration quantity of the battery charger are input into the consumption model, and a parameter, corresponding to the minimum output from the consumption model, of the electric bus serves as an optimal parameter of the electric bus. According to the parameter configuration method and device of the electric bus, the technical problem that in the prior art, optimal quantity configuration of a power battery and the battery charger cannot be obtained due to the fact that the battery capacity of the electric bus and the quantity of the battery charger are not considered by electric bus operation is solved.