The invention discloses a design system and method of a domain model framework. The system comprises a display layer, a business layer and a data layer, wherein the display layer comprises a customization command module and a Windows presentation basic module, the business layer comprises a service module and a verification module, and the data layer comprises an object relation mapping module and a database. The system further comprises a distributed entity class and an application model which penetrates the display layer, the business layer and the data layer. The design system and method has the advantages that repetitive work and error probability can be reduced, and each module of a project is designed by one mode.