The invention relates to the technical field of integrated circuits and particularly relates to a reverse connection protection circuit, an H-bridge output drive chip and an application of the drive chip. The reverse connection protection circuit is used for being arranged between a chip power supply terminal and a common power supply terminal; the chip power supply terminal provides the common power supply terminal with voltage through an output NMOS tube; the chip power supply terminal is also connected to a gate of the output NMOS tube through a Zener diode or a resistor with large enough resistance; the gate of the output NMOS tube is also connected to a boost output end through a control PMOS tube; the voltage provided by the boost output end is greater than that provided by the chip power supply end; and the gate of the control PMOS tube is connected to the common power supply terminal. The H-bridge output drive chip comprises the reverse connection protection circuit. The reliability of the drive chip can be improved and the manufacturing cost can be reduced.