The invention discloses an intelligent selection method of an information channel based on load balance. The intelligent selection method comprises the following steps: distributing concurrent data to a plurality of external network front-end computers in a plurality of channels through load balance hardware; inserting data into data sheets of a plurality of isolating devices through the plurality of external network front-end computers; acquiring data in the data sheets of the plurality of isolating devices through a plurality of internal network front-end computers; processing data by an internal network server and storing the processed data into an internal network database; scanning the internal network database through the plurality of internal network front-end computers in real time and formatting the data in the internal network database; inserting the formatted data into the data sheets of the plurality of isolating devices through the plurality of internal network front-end computers; obtaining the formatted data in the data sheets of the plurality of isolating devices through the plurality of external network front-end computers and sending the data to each channel. According to the intelligent selection method provided by the invention, the data processing capability is improved through a multi-channel intelligent selection method under the condition of generating a lot of requirements of consultation and business processing and the like; meanwhile, a condition that a whole transmission line is blocked, caused by the fact that a single device has faults, can be avoided.