The invention discloses a hirudinaria manillensis lesson breeding method. The hirudinaria manillensis lesson breeding method comprises the steps that shrimp and crabdioctyl divinyltriamino glycine and a ginger agent are applied to a breeding water body at intervals of 10-15 days, is continuously applied for 1-3 days and is applied one time every day, wherein the shrimp and crabdioctyl divinyltriamino glycine amount and the ginger agent amount applied to per cubic meter of breeding water body are 3-6 ml and 2-7 g respectively; sicken hirudinaria manillensis lessons are transferred into a sicken hirudinaria manillensis lesson treatment pond, tricylazole II is applied firstly and is continuously applied for 3-5 days at intervals of 1-3 days, then tricylazole III is applied and is continuously applied for 3-5 days, and the tricylazole II and the tricylazole III are applied one time every day, wherein the tricylazole II amount and the tricylazole III amount applied to per cubic meter of breeding water body in the sicken hirudinaria manillensis lesson treatment pond are 1-3 g and 1-3 g respectively. A water body environment of the breeding pond is greatly improved, the morbidity of hirudinaria manillensis lessons is reduced, and the survival rate of the hirudinaria manillensis lessons is improved.