The invention discloses an apparatus washing and disinfection device for a surgical operation. The apparatus washing and disinfection device comprises a support, the upper end of the support is provided with a supporting table board, one side of the upper end of the support table board is provided with a cleaning box, the upper end of the cleaning box is provided with a box cover, the upper end of the box cover is fixedly connected to a washing device, the upper end of the washing device is communicated with a disinfection liquid box through a pipeline, a valve is formed between the output end of the disinfection liquid box and the washing device, the cleaning box is internally provided with an apparatus fixing plate, the lower end of the cleaning box is communicated with a discharging pipe, the lower end of the discharging pipe is provided with a sewage filtering device, one end of the sewage filtering device is provided with a circulating pipe, one end of the circulating pipe is communicated with the washing device, one side of the cleaning box is connected to a slide channel in a penetrating mode, one end of the slide channel is provided with a drying device, and the other end of the slide channel is arranged on one side of the apparatus fixing plate. The apparatus washing and disinfection device can effectively reduce discharging of sewage, after cleaning is finished, an operation apparatus can be subjected to drying operation, and thus the apparatus washing and disinfection device is convenient to use. The invention further provides an apparatus washing and disinfection method for the surgical operation.