The invention provides a medicine screening machine. The medicine screening machine comprises a baseplate, a vertical frame plate fixed in middle of the baseplate, a rotating shaft for penetrating through the frame plate, an annular turntable annuarly sleeved on the rotating shaft, a screen and a storage box; a support rod is arranged in an annular ring of the turntable, and is provided with a fixed block in the length direction of the support rod; a rotating plate hinged with the frame plate is arranged on the outer side of the frame plate; a strip-shaped hollow groove is formed in middle of the rotating plate; the fixed block extends into the hollow groove; a triangular frame is arranged at the top of the frame plate, and is fixed with a long plate perpendicular to the triangular frame; a chute is formed in the long plate in the length direction of the long plate; a slide block is arranged in the chute; the screen is fixed on the slide block; a cylindrical guide rod is fixed in middle of the slide block; an U-shaped groove is formed in the top of the rotating plate; and the guide rod is fixed at the bottom of the U-shaped groove. The rotating shaft rotates to drive the rotating plate to move left and right so as to drive the slide block to move left and right to realize mobile screening of medicines in the screen; and the medicine screening machine is simple in structure and high in practicability.