The invention discloses a manufacturing method of an iron picture core and an iron picture vase comprising the iron picture core, and belongs to the technical field of conventional iron picture crafts. To overcome the defects of a conventional product, the manufacturing method of the iron picture core is characterized in that the whole picture core or partial picture core is obtained through mold pouring. The manufacturing method comprises the following steps of: dividing an original iron picture into a plurality of body blocks; making the mold of each body block; performing pouring by each mold to obtain the solid body of the corresponding body block; and combining the solid bodies to obtain the complete picture core, or combining the solid bodies with the original iron picture which is not easy to form by performing pouring to obtain the complete picture core, wherein raw materials for pouring the solid bodies comprise one kind or a mixture of two or more kinds of metallic materials, non-metallic materials, and organic materials.