The invention provides a method for synthesizing chiral sulfanilamides through asymmetric intramolecular reduction and amination under catalysis of palladium. A catalysis system used in the method is a chiral diphosphine complexe. Corresponding chiral sulfanilamides are obtained through reduction and amination of a simple and easily available ketoamine substrate, and enantiomeric excess can reach 99%. The method is simple to operate, practical and feasible; raw materials are simple and easily available; the catalyst is commercially available; and reaction conditions are mild. Moreover, high enantioselectivity, good yield and environment friendliness are realized in synthesis of chiral sulfanilamides through asymmetric reduction and amination.