The invention relates to a wire guide and cutting device of a winding machine, which comprises a fixed wire guide plate, a movable wire guide plate, a first mounting plate and a second mounting plate, wherein directions of the first mounting plate and the second mounting plate are consistent with that of a copper wire; a plurality of wire guide holes are formed in the fixed wire guide plate and the movable wire guide plate; a driving air cylinder is fixedly arranged on the side surface of the second mounting plate; a through groove is formed in the side surface of the first mounting plate; one end of the fixed wire guide plate is fixedly connected with a movable end of the driving air cylinder; the other end of the fixed wire guide plate extends into the through groove; slide rails and slide blocks are arranged on the opposite side surfaces of the first mounting plate and the second mounting plate; the two ends of the movable wire guide plate are fixedly connected with the two slide blocks respectively; the wire guide and cutting device further comprises a drive device driving the slide block to move; during winding, wire guide is performed by the wire guide holes in the fixed wire guide plate and the movable wire guide plate; during cutting, the drive device drives the slide blocks to move to further drive the movable wire guide plate to move to be clung to the fixed wire guide plate; then, the driving air cylinder drives the fixed wire guide plate to move to be matched with the movable wire guide plate for cutting; and wire guide and cutting effects are good.