The invention discloses a nephrology department enema type penetration treatment device. The device comprises an outer tube and an inner tube, the upper end of the outer tube and the upper end of the inner tube are connected through an annular connecting part, a lubricant outlet is formed in the upper surface of the annular connecting part, a liquid medicine outlet is formed in the upper end of the inner tube, an air bag is arranged at the upper portion of the outer side face of the outer tube, a handle is arranged at the lower portion of the outer side face of the outer tube, an airway tube and a lubricant catheter are arranged between the outer tube and the inner tube, one end of the airway tube penetrates through the side face of the outer tube and is communicated with the internal portion of the air bag, the other end of the airway tube is connected with the outlet of an air pump, the air bags makes the diameter of the outer tube smaller than the diameter of an existing outer tube and makes the outer tube fixed inside a patient, the liquid medicine is not prone to leakage, the enema process is stable, the experience comfort level of the patient is high, and the structure is concise; a heating device and a temperature sensor are used cooperatively for making the temperature of the liquid medicine constant; vanes are fixed to prevent laminar conditions in the stirring process of the liquid medicine and to prevent the liquid medicine from generating precipitation.