The invention relates to a profile control well selection decision-making method suitable for an offshore heavy oil reservoir. The profile control well selection decision-making method comprises the following steps that (1), single factor indexes in profile control well selection decision-making are divided according to index properties; (2), the numerical value of a comprehensive evaluation index of a water injection well to be evaluated is calculated; (3), the average value of comprehensive evaluation indexes of water injection wells of a block is calculated; and (4), the numerical value, obtained in the step (2), of the comprehensive evaluation index of the water injection well to be evaluated is compared with the average value, obtained in the step (3), of the comprehensive evaluation indexes of the water injection wells of the block so as to decide whether the water injection well to be evaluated needs to be subjected to a profile control measure or not. The method has the following advantages that (1), the influence of the viscosity of crude oil is fully considered in offshore heavy oil reservoir profile control well selection decision-making, so that the profile control well selection decision-making method is more accurate; and (2), all weight values are calculated through an analytic hierarchy process method, and the influence of human factors is removed, so that the profile control well selection decision-making method is more scientific and reasonable.